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Molecular and antigen tests, and sample types for diagnosis of COVID-19: a review – Supplementary Tables

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posted on 2022-07-01, 09:05 authored by Yujia Zhang, Rachael Garner, Sana Salehi, Marianna La Rocca, Dominique Duncan

Laboratory tests seeking to improve detection of COVID-19 have been widely developed by laboratories

and commercial companies. This review provides an overview of molecular and antigen tests, presents

the sensitivity and specificity for 329 assays that have received US FDA Emergency Use Authorization and

evaluates six sample collection methods – nasal, nasopharyngeal, oropharyngeal swabs, saliva, blood and

stool.Molecular testing is preferred for diagnosis of COVID-19, but negative results do not always rule out

the presence of infection, especially when clinical suspicion is high. Sensitivity and specificity ranged from

88.1 to 100% and 88 to 100%, respectively. Antigen tests may be more easy to use and rapid. However,

they have reported a wide range of detection sensitivities from 16.7 to 85%, which may potentially yield

many false-negative results.

Funding

National Science Foundation under award no. 2027456 (COVID-ARC)

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    Future Virology

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    Keywords

    COVID-19diagnostic testingSARS-CoV-2sensitivity and specificityUS FDA

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    CC BY-NC-ND 4.0

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