Nanomedicines in oral cancer: inspiration comes from extracellular vesicles and biomimetic nanoparticles - Supplementary dataset

<p>Oral cancer is a common life-threatening malignancy having high mortality and morbidity rates. During</p> <p>the treatment process, individuals unavoidably experience severe side effects. It is essential to develop</p> <p>safer and more effective strategies. Currently, extracellular vesicles (EVs) and biomimetic nanoparticles are</p> <p>nanomedicines with long-term blood circulation and lower off-target toxicity that orchestrate immune</p> <p>responses and accumulate specifically in tumor sites. EVs create a synergetic effect by encapsulating</p> <p>drugs and collaborating with naturally loaded elements in the EVs. Biomimetic nanoparticles retain the</p> <p>characteristic features of the synthetic nanocarriers and inherit the intrinsic cellmembrane functionalities.</p> <p>This review outlines the properties, applications, challenges, pros and cons of EVs and biomimetic</p> <p>nanoparticles, providing novel perspectives on oral cancer.</p>