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Polymerizable dye for colored particles synthesis with potential use in immunoassays
dataset
posted on 2019-06-08, 10:22 authored by Anabela L. Femia, Verónica D. G. Gonzalez, Valeria Garcia, Luis M. GugliottaLatex-particles are suitable for diagnosis purpose since they are able to interact with biological molecules. In this work, a colored monomer was synthesized between basic fuchsine(BF) and glycidyl methacrylate(GMA). BF-GMA obtaining was verified through UV-Vis, IR, NMR and Mass spectrometry. The synthesis of colored particles by emulsion polymerization of styrene and the BF-GMA monomer was studied by measuring conversion, particle diameter, BF incorporation, surface charge densities and also in a protein binding assay. Results confirmed the production of stable particles, with controlled size and high BF incorporation, capable of interacting with proteins efficiently, and being used in an immunoagglutination test.