lsrt_a_1783312_sm4714.cif (26.85 kB)

Synthesis and crystal structure of a new Zn(II) complex with anti-leukemia activity

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posted on 02.07.2020, 14:14 by Shang-Liang Chen, Xiao-Yan Liu, Shao-Chang Li, Chaoyu Wu, Zhi-Yi Li, Ting-Ting Li

A new Zn(II)-containing coordination complex [ZnBrL] (1) based on the Schiff base ligand(E)-1-(((3-(piperidin-1-yl)propylidene)amino)methyl)naphthalen-2-ol (HL) has been successfully prepared using a slow volatilization method. A mechanical grinding method was applied for preparing the crystalline complex 1 in the nano-region, which was studied by both of the scanning electron microscopy and transmission electron microscopy. In addition, its inhibitory effect on ARH-77 human leukemia cells were evaluated. First, the Cell Counting Kit-8 detection kit was used to detect the influence of nano 1 on the cell viability. Next, the cell colony formation assay was conducted for the determination of the cell proliferation. The trans-well assay was performed to explore the migration and invasion of the cells after nano 1 treatment.


This work was supported by the grants from the National Natural Science Foundation of China (No. 81871655), the National Key Research and Development Program (No. 2017YFD0500301).