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Use of Capillary Electrophoresis Migration Position for the Presumptive Identification of Hemoglobin Variants Prevalent in China

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posted on 2023-01-25, 11:20 authored by Miao Xu, Ming-Yang Li, Yu Zeng, Weijie Xie, An-Ping Xu, Ling Ji

Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.

Funding

This study was supported by Weifang Health Committee Foundation [WFWSJK-2021–204] and Guangdong Medical Science Foundation [B2021064].

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