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Per1 mutation enhances masking responses in mice

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Version 2 2022-10-11, 08:43
Version 1 2022-10-03, 09:40
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posted on 2022-10-03, 09:40 authored by Nemanja Milićević, Arthur A. Bergen, Marie-Paule Felder-Schmittbuhl

Light can restrict the activity of an animal to a diurnal or nocturnal niche by synchronizing its endogenous clock (entrainment) which controls the sleep wake cycle. Light can also directly change an animal’s activity level (masking). In mice, high illumination levels decrease activity, i.e. negative masking occurs. To investigate the role of core circadian clock genes Per1 and Per2 in masking, we used a 5-day behavioral masking protocol consisting of 3 h pulses of light given in the night at various illuminances (4–5 lux, 20 lux and 200 lux). Mice lacking the Per1 gene had decreased locomotion in the presence of a light pulse compared to wild-type, Per2 and Per1 Per2 double mutant mice. Per2 single mutant and Per1 Per2 double mutant mice did not show significantly different masking responses compared to wild-type controls. This suggests that Per1 suppresses negative masking responses in mice.

Funding

This research was supported by the Oskar Öflunds Foundation, Ella and Georg Ehrnrooth Foundation, the Academy of Finland [decision number: 340127], NeuroTime Erasmus+ of the European Commission and the Centre National pour la Recherche Scientifique, France.

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