Nanotherapeutic potential of antibacterial folic acid-functionalized nanoceria for wound-healing applications - Supplementary figures

Aim: The functionalization and characterization of antibacterial nanoceria with folic acid (FA) and

elucidation of their in vivo wound healing application. Materials & methods: Functionalization of

nanoceria were done with FA using a chemical method and their antibacterial activity, cellular

biocompatibility and in vivo wound healing application were evaluated. Results: The functionalization

of nanoceria with FA was done with 10 to 20 nm size and -20.1 mV zeta potential. The nanoformulation

showed a bacteriostatic effect along with biocompatibility to different cell lines; 0.1% w/v spray of

FA-nanoceria demonstrated excellent wound healing capacity within 14 days in a Wister rat model.

Conclusion: The antioxidant and reactive oxygen species scavenging activity of the FA-nanoceria make it a

promising therapeutic agent as a unique spray formulation in wound healing applications.