the Ministry of Education, (Grant / Award Number23/01/2023:: 'GKE-ZZ202019,GKE-ZZ202149') National Natural Science Foundation of China, (Grant / Award Number: 'No. 82260714') the Program of Key Laboratory of High-Incidence-Tumor Prevention and Treatment, (Grant / Award Number: 'Guangxi Medical University') Natural Science Foundation of Guangxi Province, (Grant / Award Number: 'No.2018GXNSFAA281064','No.2020GXNSFDA238016')