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Supplementary Figure 1. Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in TP53 mutant pancreatic tumors

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Version 2 2019-03-21, 10:33
Version 1 2019-03-21, 10:27
posted on 2019-03-21, 10:33 authored by Pilar Acedo, Aristi Fernandes, Joanna Zawacka-Pankau
Supplementary Figure 1. PpIX and BPD induce ROS generation.
(a) PpIX and BPD generated ROS in Panc1 cells as assessed by HE staining. Pre-treatment with 4 μM resveratrol reverted the effect of these compounds. Representative histograms of three independent experiments are shown.
(b) Neither, PpIX nor BPD induced ROS in non-transformed HPDE cells (DCFDA staining). H2O2 treatment was used as positive control of ROS induction. The representative histograms are shown (n=3).


The work has been supported by Karolinska Institutet/MD Anderson Cancer Center Sister Institution Network Fund (SINF) and The Strategic Research Program in Cancer (StratCan), Stockholm Läns Landsting (SLL) and Åke Wibergs stiftelse