nnm-2021-0241 - Supplementary Figure 2 In vivo biodistribution and tumor accumulation of A) ICG and B) PLN

A. Upper panel: Representative back and abdomen images of tumor bearing mice with IV injected ICG at various times up to 24 h. Lower panel: Ex vivo imaging of various organs at 4 and 24 h of post treatment with ICG. B. Upper panel: Representative back and abdomen images of tumor bearing mice with IV injected PLN at various times up to 24 h. Lower panel: Ex vivo imaging of various organs at 4 and 24 h of post treatment with PLN (ICG labelled). The numbers (1-6) mark organs as follows: 1) Tumor; 2) heart; 3) liver; 4) spleen; 5) lung; 6) kidney. The fluorescence intensity is directly proportional to the concentration of ICG or ICG labelled PLN.