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A new Cu3Al-layered double hydroxide heterogeneous catalyst for azide-alkyne [3 + 2] cycloaddition reaction in water

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journal contribution
posted on 05.08.2022, 18:20 authored by Noura Aflak, Lekbira EL Mersly, Hicham Ben EL Ayouchia, Salah Rafqah, Hafid Anane, Miguel Julve, Salah-Eddine Stiriba

A new Cu3Al-layered double hydroxide (LDH) compound that contains Cu2+ and Al3+ in a 3:1 copper to aluminum molar ratio was synthesized by a coprecipitation method at constant pH and characterized by various methods. Cu3Al-LDH was efficiently used as a catalyst for the regioselective click of 1,4-disubstituted-1,2,3-triazoles by [3 + 2] cycloaddition of several azides and alkynes in water under ambient conditions. The investigated heterogeneous Cu3Al-LDH catalyst was used in lower copper catalyst loading in absence of any additive reducing agent, showing good stability in terms of copper species leaching as well as reusability associated to the loss of the layered structure to some extent during the process of filtration-dehydration.

Funding

The Ministerio Español de Economía y Competitividad (Project PID2019-109735GB-I00) and the Université Cadi Ayyad (UCA) are acknowledged for their support of this work.

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