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A new iridoid glucoside from the roots of Morinda officinalis

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posted on 2023-05-26, 08:20 authored by Le Thi Huyen, Nguyen Thi Hien, Nguyen Viet Duy Anh, Vu Mai Thao, Nguyen Thi Kim Thoa, Nguyen Thi Minh Hang

A new iridoid glucoside, moridoside (1), and nine known compounds, asperulosidic acid (2), 6-O-epi-acetylscandoside (3), geniposidic acid (4), 2-hydroxymethylanthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), damnacanthol (7), lucidine-ω-methyl ether (8), 2-hydroxy-1-methoxyanthraquinone (9), and 3,8-dihydroxy-1,2-dimethoxyanthraquinone (10) were isolated from the methanol extract of Morinda officinalis How. roots. Their structural identification was carried out based on the spectroscopic evidence. All compounds were evaluated for their nitric oxide (NO) production inhibitory activities in LPS-stimulated RAW264.7 macrophages. Compounds 5-7 significantly inhibited the production of NO with IC50 values of 28.4, 33.6, and 30.5 μM, respectively.

Funding

Le Thi Huyen, ID VNU.2021.TTS.12, thanks The Development Foundation of Vietnam National University, Hanoi for sponsoring this research.

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