gnpl_a_1224868_sm9971.pdf (575.87 kB)
A new piperidine alkaloid from the leaves of Microcos paniculata L.
journal contribution
posted on 2016-08-24, 10:30 authored by Gang Zhang, Na Zhang, Li Xu, Hong-Tan Wu, Dan Chen, Qi-Huang Lin, Lian-Zhong LuoA new piperidine alkaloid, microcosamine C (1), and one known compound, microcosamine A (2) were isolated from the leaves of Microcos paniculata. Structure elucidation was carried out using HR-ESI-MS, 1D and 2D NMR spectroscopic methods and by comparison with data reported in the literature. The absolute configuration at the C-3 hydroxy group of 1 was established by a Mosher esterification procedure. Both the isolates (1–2) were evaluated for cytotoxicity against four selected tumour cell lines and showed only weak activity against RAW 264.7 cell line.