posted on 2023-01-03, 06:00authored byRafael Dias do Espírito Santo, Bianca Nascimento Monteiro da Silva, Jaime A. Rabi, Vagner D. Pinho
Alkylation of thiopurine derivatives with alcohols by the Mitsunobu reaction are reported in moderated to good yields. The method was applied in synthesis of number of thiopurine and thiopurine ribosides derivatives.
Funding
This work was supported by the by the Brazilian National Research Council (CNPq), under grant (403543/2020-7) and the Brazilian Company of Research and Industrial Innovation (EMBRAPII, under grant 015/2020).