An efficient synthesis of 4,5-disubstituted 1,2,3-triazoles by three-component reaction between sodium azide, ethyl cyanoacetate or malonitrile and arylglyoxals
posted on 2024-02-12, 07:00authored byAkram Ranjbar Derranji, Mohammad Anary-Abbasinejad
Three-component reaction between sodium azide, ethyl cyanoacetate or malonitrile and arylglyoxals afforded 4,5-disubstituted 1,2,3-triazole derivatives in high yields. All reactions were conducted in ethanol as an environmentally benign solvent at room temperature without using any catalyst or modifier. Stable solid products were easily isolated and purified by washing with water and diethyl ether. The structures of the compounds were proved by 1H and 13C NMR and IR spectral and elemental analysis data.