Antifungal fatty acid derivatives against Penicillium italicum from the deep-sea fungus Aspergillus terreus SCSIO 41202

The present work reports the bioassay-guided isolation of four bioactive fatty acid derivatives involving a new butenolide, namely sinulolide I (1) together with three known metabolites (2–4) from the deep-sea sediment derived fungus Aspergillus terreus SCSIO 41202. The chemical structure of compound 1 was elucidated based on extensive spectroscopic methods (1D/2D NMR and HR-ESI-MS), optical rotation and circular dichroism analyses, while the structures of the known compounds (2–4) were established by comparison of NMR spectral data with those reported in literature. All of these four compounds (1–4) exhibited significant antifungal activity against citrus postharvest pathogen Penicillium italicum (MICs around 0.031–0.125 mg/mL).