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CTAB promoted CuI catalyzed green and economical synthesis of 1,4-disubstituted-1,2,3-triazoles
journal contribution
posted on 2018-03-27, 00:58 authored by Abdul Aziz Ali, Rahul Sharma, Prakash J. Saikia, Diganta SarmaA practical, straightforward, and highly efficient CuI mediated green protocol for the regioselective synthesis of 1,4-disubstituted-1,2,3-triazole was developed using cetyltrimethylammonium bromide as a cheap additive in good to excellent yields. Low catalyst loadings, environmentally friendly solvent, wide substrate scope and short reaction times at room temperature make this strategy more accessible and safe.