posted on 2019-12-07, 14:30authored byAshraf M. Omar, Dya Fita Dibwe, Ahmed M. Tawila, Sijia Sun, Min Jo Kim, Suresh Awale
The 70% ethanolic extract of Artemisia vulgaris showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition with PC50 12.5 μg/mL. A phytochemical investigation of this extract yielded a new bicyclic [4:3:0] sesquiterpene named (+)-vulgaric acid (1), together with eight previously reported compounds. The structural elucidation of 1 was achieved by HRFABMS and NMR analysis. The absolute configuration of 1 was deduced by computational calculations of ECD data. All isolated compounds were tested for preferential cytotoxicity against PANC-1 cells, and apigenin (3) showed the strongest activity with PC50 30.7 μM.
Funding
This work was supported by the Japanese Society for the Promotion of Science (JSPS), Japan, Kakenhi (16K08319) and Kobayashi International Scholarship Foundation to S.A.