posted on 2024-06-26, 13:00authored byHong-Lian Chen, Jia-Ying Yao, Ming-Hui Gao, Jun-Jie Tan, Shi-Jin Qu, Shi-Jun He, Chang-Heng Tan
Twelve compounds, comprising of four new ones, 6β,7α-limondiol (1) and ethyl 19-hydroxyisoobacunoate diosphenol (2), N-benzoyl 3-prenyltyramine (9) and 9-O-methyl integrifoliodiol (12), were isolated from the twigs with leaves of Tetradium trichotomum. The structures were elucidated by analysis of MS, NMR, and single-crystal X-ray diffraction. Compounds 1, 6, 8, 9 and 12 exhibited immunosuppressive activities in vitro against the proliferation of ConA-induced T lymphocytes and LPS-induced B cells.
Funding
This work was financially supported by the National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China under Grant No. 2019ZX09201001.