ganp_a_1373100_sm1503.pdf (2.01 MB)
Cytotoxic 8,9-seco-ent-kaurane diterpenoids from Croton kongensis
journal contribution
posted on 2017-09-12, 12:16 authored by Shu-Qin Shi, Yao-Yue Fan, Cheng-Hui Xu, Jian Ding, Guan-Wu Wang, Jian-Min YueChemical study on the ethanolic extract generated from the aerial parts of Croton kongensis led to the isolation of three new 8,9-seco-ent-kaurane diterpenoids, kongeniods A‒C (1‒3), together with seven known analogs (4–10). The structures of these compounds were assigned by spectroscopic data analysis. The vitro cytotoxic tests showed that compounds 1–3 exhibited strong activities against HL-60 cell lines with IC50 values of 0.47, 0.58, and 1.27 μM, respectively.