Taylor & Francis Group
Browse
gnpl_a_1786829_sm4029.pdf (1.24 MB)

Cytotoxic and immunomodulatory phenol derivatives from a marine sponge-derived fungus Ascomycota sp. VK12

Download (1.24 MB)
journal contribution
posted on 2020-07-02, 12:33 authored by Tran Hong Quang, Nguyen Viet Phong, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Thi Thanh Ngan, Hyuncheol Oh, Nguyen Hoai Nam, Chau Van Minh

Chemical investigation of the marine-derived endophytic fungus Ascomycota sp. VK12 resulted in isolation and identification of a new compound, (3R)-(3′,5′-dihydroxyphenyl)butan-2-one (1) and five known ones: AGI-7 (2), sescandelin (3), sescandelin-B (4), 4-hydroxybenzaldehyde (5), and hydroxysydonic acid (6). The absolute configuration of 1 was determined by time-dependent density functional theory electronic circular dichroism, specific optical rotation, and NMR calculations. Compounds 1 and 2 showed cytotoxicity towards HepG2, MCF-7, and SK-Mel2 carcinoma cells, with IC50 values ranging from 48.6 to 96.5 µM. Compounds 1, 2, 4–6 displayed NO inhibitory effects in LPS-stimulated BV2 cells, with IC50 values in a range from 24.2 to 76.5 µM. Compound 2 further inhibited PGE2 overproduction, with an IC50 value of 25.3 µM. The inhibitory effects of 2 towards NO and PGE2 overproduction were found to have a close relationship with its suppression of iNOS and COX-2 protein expression, respectively.

Funding

This work was financially supported by Vietnam Academy of Science and Technology (VAST) under grant number VAST04.05/19-20.

History