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Enhancement of antibiotic activity by phytocompounds of Turnera subulata

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journal contribution
posted on 2019-02-14, 10:25 authored by Cicero L. A. Freitas, Francisca F. P. Santos, Orlando M. Dantas-Junior, Vital V. Inácio, Edinardo F. F. Matias, Lucindo J. Quintans-Júnior, José J. S. Aguiar, Henrique D. M. Coutinho

The present study aimed to evaluate the antibacterial and modulatory activity of the Turnera subulate methyl extract in isolation or in combination with aminoglycoside antibiotics, using the microdilution method. The Turnera subulata methyl extract was used in isolation in the antibacterial assays and in combination with antibiotics in the modulation assays. All tests were performed in triplicates. The Turnera subulata methyl extract presented both antibacterial and antibiotic-modulatory effects in vitro, in isolation and in association with aminoglycosides. The extract activity depends on the bacterial strain and may be associated with the presence of tannins and flavonols. However, further studies are required to characterize the Turnera subulata potential for the development of new drugs against multiresistant bacteria.

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