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Genome-wide association study for reproduction-related traits in Chinese domestic goose

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journal contribution
posted on 05.08.2022, 17:00 authored by G. Gao, P. Chen, C. Zhou, X. Zhao, K. Zhang, R. Wu, C. Zhang, Y. Wang, Y. Xie, Q. Wang

1. This study measured six reproduction traits in a Sichuan white goose population (209 individuals), including fertility, qualified egg rate, plasma concentrations of progesterone (P), follicle-stimulating hormone (FSH), prolactin (PRL) and oestrogen (E2).

2. Whole-genome resequencing data from the same goose population (209 individuals) were used in a genome-wide association study (GWAS) utilising a mixed linear model to investigate the genes and genetic markers associated with reproduction traits. The frequency of the selected SNPs and haplotypes were determined using the Matrix-Assisted Laser Desorption Ionisation Time-Of-Flight Mass Spectrometry (MALDI-TOF MS) method.

3. In total, 42 SNPs significantly associated with these traits were identified. A haplotype block was constructed based on five SNPs that were significantly associated with qualified egg rate, with individuals having the haplotype CCTTAAGGAA having the lowest qualified egg rate.

4. In conclusion, these results provided potential markers for marker-assisted selection to improve goose reproductive performance and a basis for elucidating the genetics of goose reproduction.

Funding

This work was sponsored by the Key R & D Project in Agriculture and Animal Husbandry of Rongchang [No.22534C-22], Chongqing Scientific Research Institution Performance Incentive Project [grant numbers cstc2019jxj10004, cstc2019jxjl80009], China Agriculture Research System of MOF and MARA [grant number CARS-42-51], Natural Science Foundation of Chongqing, China [grant number cstc2019jcyj-msxmX0072];Sichuan provincial department of science and technology project [2021YFS0379].

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