posted on 2019-01-18, 06:53authored byJing Ding, Zhijun Yang, Yu Zhao, Weizhen Fang, Qun Lu
Ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester.
Novozyme 435 catalyzed hydrolysis reaction to prepare the key intermediate for the synthesis of peptide side chain of ergopeptides.
Funding
This work was supported by the Fundamental Research Funds for the Central Universities under [grant number 2682016CX105].