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Lipase-catalyzed synthesis of ethyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate: a useful combination of chemical synthesis with enzymatic methods
journal contribution
posted on 2019-01-18, 06:53 authored by Jing Ding, Zhijun Yang, Yu Zhao, Weizhen Fang, Qun LuEthyl (R)-2-benzyloxy-2-isopropylhydrogenmalonate is a key intermediate for the synthesis of the side chain in ergopeptines. In this work, we adopted a method to prepare enantiomerically pure title monoester via immobilized Candida antarctica lipase B (Novozym 435)-catalyzed hydrolysis of the corresponding diester.
Novozyme 435 catalyzed hydrolysis reaction to prepare the key intermediate for the synthesis of peptide side chain of ergopeptides.