gnpl_a_1509331_sm1604.pdf (2.35 MB)
Microbial transformation of isocoronarin D by Cunninghamella echinulata NRRL 1386
journal contribution
posted on 2018-11-20, 09:58 authored by Ratchanaporn Chokchaisiri, Waraluck Chaichompoo, Oratai Sukcharoen, Apichart Suksamrarn, Lucksagoon GanranooThe diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3β-hydroxyisocoronarin D (2), 6α-hydroxyisocoronarin D (3) and 3β,7α-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.