Microwave-assisted and catalyst-free sulfenylation of imidazo[2,1-b]thiazoles with sulfonyl hydrazides in water

An efficient microwave-assisted and catalyst-free sulfenylation of imidazo[2,1-b]thiazoles with sulfonyl hydrazides has been developed in water. This method is practical and environmental friendly, and can be performed within a short reaction time. The sulfenylation reaction shows high regioselectivity, and excellent functional-group compatibility, giving the desired products in moderate to good yields.