Microwave-assisted preparation of azachalcones and their N-alkyl derivatives with antimicrobial activities

Two new azachalcones were prepared by both Claisen–Schmidt condensation and a simple environmentally trendy microwave-assisted method. Ten new N-alkyl (C_6,8,10,12,14)-substituted azachalconium bromides (3a–e, 4a–e) were prepared from compounds 1 and 2 with corresponding alkyl halides. The antimicrobial activities of all the compounds were tested against Enterococcus faecalis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus micro-organisms.