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New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793

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posted on 2020-04-27, 02:12 authored by Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noritaka Kagaya, Noriaki Sakata, Toshio Tsuchida, Kazuo Shin-ya

Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1), MBJ-0031 (2) and MBJ-0032 (3). Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 13 were determined by modified Mosher’s and Marfey’s methods. In addition, cytotoxic and antimicrobial evaluations of the compounds were conducted.

The structure of new phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793.

Funding

This work was supported in part by the grant “Project focused on developing key technology of discovering and manufacturing drug for next-generation treatment and diagnosis“.

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