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Novel phenylpropanoids and isoflavone glycoside are isolated and identified from the carob pods (Ceratonia siliqua L.)

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journal contribution
posted on 14.05.2022, 12:00 authored by Zhi-Tian Peng, Ying-Jie Xia, Takuya Yashiro, Xiong Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsim, Huai-You Wang

Two new phenylpropanoids (1 and 2) and one new isoflavone glycoside (3), along with nine known compounds (4  12), were isolated from the pod of Ceratonia siliqua L. Their chemical structures were elucidated based on extensive spectroscopic analyses (1 D and 2 D NMR, UV, IR, and HRESIMS) and compared with the literature data. In addition, all isolated compounds were evaluated in vitro for inhibitory activity against acetylcholinesterase (AChE). Compounds 4, 5, and 12 showed inhibitory activity against acetylcholinesterase (AChE) with IC50 values ranging from 15.0 to 50.2 μM.

Funding

This work was supported by Special project of Foshan University of science and technology in 2019 (FSUST19-SRI10) and Shenzhen Science and Technology Innovation Committee (ZDSYS201707281432317; JCYJ20170413173747440; JCYJ20180306174903174).

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