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One new phenylpropanoid glycoside from Myxopyrum smilacifolium with α-glucosidase inhibitory activity

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journal contribution
posted on 25.11.2021, 11:20 by Nguyen Quoc Vuong, Vu Van Chien, Nguyen Thi Hue, Pham Thi Hang, Nguyen Hoai Nam, Pham Van Cuong, Nguyen Xuan Nhiem

One new phenylpropanoid glycoside, myxosmoside I (1) and six known compounds, arenarioside (2), verbacoside (3), 3-formylindole (4), 5-hydroxymethyl furfural (5), D-manitol (6), and glycerol monooleate (7) were isolated from the roots of Myxopyrum smilacifolium (Wall.) Blume. Their chemical structures were determined by 1D-, 2D-NMR, and mass spectra, chemical methods, and compared with those reported in the literature. All compounds were evaluated for α-glucosidase inhibitory effect. Among them, phenylpropanoid glycosides 13 significantly inhibited α-glucosidase activity with IC50 values of 30.0 ± 0.9, 66.6 ± 2.3, and 36.9 ± 2.0 µM, respectively.

Funding

The authors are grateful for the Institute of Marine Biochemistry’s financial support under grant number HSB20-TN01.

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