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Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1

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posted on 2021-04-24, 05:40 authored by Hao-Bing Yu, Bo Hu, Jie Kong, Yun-Hai Li, Ying He, Xiao-Ling Lu, Bing-Hua Jiao, Xiao-Yu Liu

Two new polyketides, palitantins B and C (1 and 2), along with one known related compound (+)-palitantin (3) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC50 value of 7.9 μM (ursolic acid as positive control, IC50 = 8.3 μM).

Funding

This research was financially supported by the National Key Research and Development Program of China (Nos. 2018YFC1406705 and 2018YFC0310900), the Shanghai Pujiang Program (No. 2020PJD082), the Natural Science Foundation of Shanghai (No. 20ZR1470600), and the National Natural Science Foundation of China (Nos. 41606173 and 81741152).

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    Journal of Asian Natural Products Research

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    Geomyces sp.polyketidePTP1B inhibitory activity

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    CC BY 4.0

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