Palladium/nickel-mediated cross coupling reaction between phosphorylamides and alkenes toward enephosphorylamides

Enephosphorylamides were herein successfully prepared from phosphorylamides and substituted alkenes. The dehydrogenative transformation took place in the presence of a combination of a palladium diacetate and nickel dichloride. The transition metal-catalyzed methodology enjoyed high efficiency and broad substrate scope. Moreover, a plausible mechanism was proposed for the oxidative C–N cross coupling protocol.