gnpl_a_1443100_sm6688.pdf (1.41 MB)
Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii
journal contribution
posted on 2018-02-26, 07:25 authored by Hao-Wen Jiang, Shan-Shan Gu, Lei Cao, Sheng-Shi Jiang, Jing Lin, Yan Chen, Ling Wang, He Jiao, Jing-Ya Li, Wei-Min Zhao, Jin-Long LiThree new acetophenones, named cynwilforones A–C (1–3), together with cynandione A (4) were isolated from the root bark of Cynanchum wilfordii (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds 1 and 4 exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of C. wilfordii possesses potential hypoglycemic activity in vitro.