Secondary metabolites isolated from Agrimonia pilosa Ledeb.

A pilot study on the ethanol extracts of Agrimonia pilosa found to have anti-α-glucosidase and anti-inflammatory activities. Subsequent chemical study afforded a new phenylethyl isocoumarin glycoside (1) and eight known compounds (2-9). The structure of 1 was elucidated by comprehensive spectroscopic analysis and chemical transformations. All compounds showed modest α-glucosidase inhibitory activity (IC₅₀ values ranging from 36.8 to 210.7 μM), which was lower than that of the positive control acarbose (IC₅₀=301.9 μM). Those compounds except inactive compounds 3 and 6 showed weak anti-inflammatory activity.