lsyc_a_1252045_sm0062.docx (2.52 MB)

Synthesis of 4-phenyloxazinones via DBU-catalyzed cleavage of 4-bromomethylcoumarins

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journal contribution
posted on 16.12.2016, 13:31 by Devadas Shamala, Kalegowda Shivashankar

A new route for ring transformation has been discovered during the reaction of 4-bromomethylcoumarins with hydroxyl amine in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), leading to the formation of pharmacologically important 1,2-oxazinones in a single step with very high yields.