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Synthesis of Novel Pyrimido[1,2-a]Pyrimidines by Fe3O4@PAP as an Efficient and Reusable Magnetic Nanocatalyst

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journal contribution
posted on 05.02.2020, 11:07 by Fatemeh Tajali Rad, Hassan Kefayati, Shahab Shariati

Novel 2-amino-1,4-dihydropyrimidines derivatives was synthesized by the reaction of guanidine hydrochloride, aromatic aldehyde and ethyl benzoylacetate under ultrasound irradiation. Then, the reaction of 2-amino-1,4-dihydropyrimidines and 3-formylchromone for the synthesis of novel pyrimido[1,2-a]pyrimidine was studied in the presence and absence of Fe3O4@PAP as catalyst. The results show that, the products in the presence of catalyst were obtained in highest yield and at least time, that confirmed the efficiency of Fe3O4@PAP.