posted on 2016-06-20, 21:02authored byJing-Xu Gong, Ya He, Zhen-Lin Cui, Yue-Wei Guo
A series of novel thiazino[3,2-a]benzimidazole derivatives synthesized by cyclization of (R)-2-(chloromethyl)oxirane with benzimidazole-2-thiol followed by reacted with benzyl bromides in high yield under milder conditions. The molecular structures of all compounds were confirmed by 1H and 13C NMR spectroscopy and Mass spectrometry. The absolute configuration of the compounds was confirmed by X-ray diffraction analysis. All the synthesized compounds were evaluated in vitro for their antituberculosis activity.