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The assessment of childhood maltreatment and its associations with affective symptoms in adulthood: Results of the German National Cohort (NAKO)

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Version 2 2024-04-29, 08:35
Version 1 2022-03-18, 16:20
journal contribution
posted on 2022-03-18, 16:20 authored by Johanna Klinger-König, Fabian Streit, Angelika Erhardt, Luca Kleineidam, Florian Schmiedek, Börge Schmidt, Nako Investigators, Michael Wagner, Jürgen Deckert, Marcella Rietschel, Klaus Berger, Hans J. Grabe

Childhood maltreatment affects 20–30% of the German population and is an important risk factor for physical and mental diseases in adult life. This study reports first results of the distribution of childhood maltreatment in the population-based mega cohort German National Cohort (NAKO) and estimates associations with affective symptoms in adulthood.

The Childhood Trauma Screener (CTS), a short version of the Childhood Trauma Questionnaire, was used in 83,995 adults (age: 20–72 years; 47.3% men) of NAKO. The five-item CTS assesses the severity of three types of childhood abuse and two types of childhood neglect.

Overall, 21,131 participants (27.5%) reported at least one type of childhood maltreatment; 14,017 participants (18.3%) reported exactly one type and 250 participants (0.3%) reported all five types of childhood maltreatment. Small differences regarding age (mean absolute deviation around the mean (MAD)=0.47), sex (MAD = 0.07) and education (MAD = 0.82) were observed. The severity of childhood maltreatment was associated with more severe symptoms of depression (β = 0.23), anxiety (β = 0.21) and perceived stress (β = 0.23) in adulthood, validated particularly for emotional abuse and emotional neglect.

The distribution of childhood maltreatment in NAKO is similar to previous reports. Additionally, our results suggest differential associations with psychopathological symptoms for the five types of childhood maltreatment.

Funding

The German National Cohort (NAKO) (www.nako.de) is funded by the Federal Ministry of Education and Research (project numbers: 01ER1301A/B/C and 01ER1511D), the federal states, and the Helmholtz Association, with additional financial support from the participating universities and the participating institutes of the Leibniz Association and the Helmholtz Association. The Helmholtz Society supports the German National Cohort witin its 'Program Oriented Funding (POF) III and IV. This work was supported by the German Federal Ministry of Education and Research (BMBF) through ERA-NET NEURON, ‘SynSchiz – Linking synaptic dysfunction to disease mechanisms in schizophrenia – a multilevel investigation’ [01EW1810] to MR, through ERA-NET NEURON ‘Impact of Early life MetaBolic and psychosocial strEss on susceptibility to mental Disorders; from converging epigenetic signatures to novel targets for therapeutic intervention’ [01EW1904] to MR.

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