posted on 2021-04-30, 17:00authored byYu-Yue Qin, Xi-Shan Huang, Xiao-Bo Liu, Tu-Xiang Mo, Zhao-Long Xu, Ben-Chao Li, Xiao-Ya Qin, Jun Li, Till F. Schӓberle, Rui-Yun Yang
Three new andrastin derivatives, 10-formyl andrastone A (1), 10-demethylated andrastone A (2) and andrastin G (3), together with four known andrastin analogues (4-7) were isolated from an endophytic fungus Penicillium vulpinum. Their structures were determined by 1 D, 2 D NMR, and the absolute configurations were further determined by experimental and calculated ECD spectra. Compound 5 exhibited significant antibacterial activity against Bacillus paratyphosus B with an MIC value of 6.25 µg·mL−1. Compounds 2 and 6 showed remarkable inhibitory activities against Bacillus megaterium with the MIC value of 6.25 µg·mL−1, respectively.
Funding
This work was supported by the National Natural Science Foundation of China [grant number 21762007], the Guangxi Natural Science Foundation of China [grant number 2018GXNSFAA281169], the Project of State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [grant number CMEMR2016-A06, CMEMR2018-C29], and the Guangxi Scholarship Fund of Guangxi Education Department.