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Two new antimicrobial monoterpenoid indole alkaloids from the roots of Rauvolfia yunnanensis

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journal contribution
posted on 05.08.2022, 16:41 authored by Wu Hao, Qin Ma-Long, Fan Kun, Gao Wen, Guo Rui-Rong, Yin Shan-Ze, Hu Wei-Yan, Zhang Lan-Chun, Zhang Rong-Ping, Yu Hao-Fei, Li Yu-Peng, Ding Cai-Feng

Two new monoterpenoid indole alkaloids 3-hydroxylochnerine (1) and 10-hydroxyvinorine (2) were isolated from the roots of Rauvolfia yunnanensis. Their structures were elucidated based on the analysis of spectroscopic data and ECD calculation. Both compounds exhibited potent antimicrobial activity against Bacillus subtilis and Escherichia coli, and their activities were comparable to the well-known antibacterial drug berberine.

Funding

The authors are grateful to the National Natural Science Foundation of China [32000274, 31900290], Yunnan Province Education Department Scientific Research Fund Project [2020J0139], the Applied Basic Research Programs of Yunnan Province [202101AU070069, 202101AY070001-066], the Yunnan Scholar of Yunling [YNWR-YLXZ-2019-019], Program Innovative Research Team in Science and Technology in Yunnan Province [202005AE160004], Expert workstation of Wang Xin-Hua in Yunnan Province [202005AF150043].

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