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Two new aspidosperma-type monoterpenoid indole alkaloids from Ervatamia officinalis

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posted on 23.06.2022, 12:00 authored by Bao-Jing Li, Yan Ma, Hai-Shan Qian, Hong-Ping He, Cui-Hong Huang, Guo-Dong Yu, Ben-Qin Tang

Two new aspidosperma-type monoterpenoid indole alkaloids, 16-O-methylvoafinine (1) and 14,15-diepi-voafinidine (2) were isolated from the aerial parts of Ervatamia officinalis. Their structures were established by comprehensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS, and electronic circular dichroism calculation. The isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and A549 cell lines by CCK-8 assay.

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81803398, U1801287), Applied Basic Research Foundation of Yunnan Province (No. 2019FB117), and the Science and Technology Planning Project of Guangdong Province (No. 2020B1111110004, 2019A1515010688), and the Science and Technology Planning Project of Guangzhou City (No. 20212210005).

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Two new aspidosperma-type monoterpenoid indole alkaloids from Ervatamia officinalis
Journal of Asian Natural Products ResearchJournal of Asian Natural Products Research

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Keywords

ApocynaceaeErvatamia officinalisaspidosperma-type alkaloidscytotoxicity

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