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Two new triterpenoid saponins from Bupleurum marginatum Wall. ex DC

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journal contribution
posted on 14.05.2022, 12:00 by Ke Luo, Rong-Ji Dai, Zhi Wang, Yan-Bo Zeng, Yu-Lin Deng, Fang Lv

Two new triterpenoid saponins (1 and 2), together with two known saponins (3 and 4) were isolated from Bupleurum marginatum Wall. ex DC. Their structures were elucidated by the comprehensive spectroscopic analysis. Compounds 1 and 2 represented the rare example of an oleanane-type triterpenoid with two sugar moieties at C-3 and C-28. The cytotoxic activity of four compounds was evaluated against normal heptocell BRL-3A in vitro.

Funding

This research was financially supported by National Natural Science Foundation of China (Grant No. 81503353) and the National Major Scientific Instruments and Equipment Development Project (Grant No. 2012YQ040140).

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