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Unconventional separation of arsenic trioxide from unused aqueous chemotherapeutic agents by direct evaporative crystallization

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journal contribution
posted on 2020-10-30, 07:00 authored by Dhanang Edy Pratama, Wen-Chen Hsieh, Kuan-Yun Lin, Yu-Ying Chen, Chun-Chou Lin, Tu Lee, Yufang Hu

An unconventional arsenic trioxide (As2O3) recovery process for unused injectable aqueous chemotherapeutic agents for leukemia treatment, having a concentration of 2 mg of As2O3/mL of H2O, was used as a case study by evaporative crystallization in a closed system under the pressures of 0.4, 0.7 and 1.0 atm. The yields for As2O3 solids recovered were 60 to 90 wt% with a purity in conformity with the As2O3 standard based on an HPLC assay. The recovered As2O3 solids were determined to be the arsenolite phase by PXRD with a particle size range of <10 μm.

Funding

This work was supported by the Ministry of Science and Technology of Taiwan, R.O.C. under grant number of 107-2218-E-008-020- and 108-2218-E-008-013.

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