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Wang resin-supported sulfonic acid-catalyzed multicomponent reaction in water leading to 4-oxo-4,5,6,7-tetrahydroindole derivatives
journal contribution
posted on 2018-06-08, 18:37 authored by Naresh Kumar Reddy Dinne, Ramamohan Mekala, S. Pulla Reddy, Ganesh Yaddanapudi Sesha Siva, Chandrasekhar Kothapalli BannoathA greener approach for the synthesis of 4-oxo-4,5,6,7-tetrahydro indole derivatives has been achieved through Wang-OSO3H-mediated three-component reaction involving dimedone, phenacyl bromide, and primary amine in water. A variety of indole derivatives were prepared using this operationally simple and straight forward methodology in acceptable yields.