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Two new resin glycosides, muricatins XII and XIII, from the seeds of Ipomoea muricata

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posted on 23.09.2022, 08:20 authored by Masateru Ono, Saki Taketomi, Hirotaka Nishikawa, Shin Yasuda, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo, Hiroyuki Miyashita, Hitoshi Yoshimitsu, Toshihiro Nohara

Two new resin glycosides, muricatins XII (1) and XIII (2), were isolated from the crude resin glycoside fraction of the seeds of Ipomoea muricata (L.) Jacq. (Convolvulaceae), along with three known ones, muricatins V (3), VI (4), and IX (5). Compounds 1 and 2 contained new glycosidic acids, muricatic acids E (1a) and F (2a), respectively. The structures of these compounds were determined using data obtained from spectroscopy measurements and chemical evidence. The results suggested that 1 and 2 have macrolactone structures (jalapins). Furthermore, the cytotoxic activity of the crude resin glycoside fraction and 35 against HL-60 human promyelocytic leukaemia cells was evaluated. All tested samples demonstrated cytotoxic activities.

Funding

This research was supported in part by a Grant-in-Aid for Scientific Research (C) (JSPS KAKENHI Grant Number JP16K08306 and JP20K07117) from Japan Society for the Promotion Science.

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