A New Synthesis Route for the Preparation of Pomalidomide

Li, Jianqi

A New Synthesis Route for the Preparation of Pomalidomide

Posted on 2016-05-24 - 07:53

A new route for the preparation of pomalidomide is described in the study. The synthetic procedure starts from 4-nitroisobenzofuran-1,3-dione and 3-aminopiperidine-2,6-dione hydrochloride via a 3 step reaction resulting in a total yield of 65% with a high HPLC purity of 99.56% and a low palladium residue level of 2 ppm. This method can be deemed as an efficient, practical and environmentally friendly synthetic route for the preparation of pomalidomide.

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A New Synthesis Route for the Preparation of Pomalidomide. Taylor & Francis. Huang, Daowei; Shen, Chengwu; Wang, Wenya; Huang, Lei; Ni, Feng; Li, Jianqi.

https://doi.org/10.6084/m9.figshare.c.3258967.v1

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