Physics

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Characterization of the ATG8-conjugation system in 2 <i>Plasmodium</i> species with special focus on the liver stage

Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage

journal contribution posted on 2025-02-24

Characterization of early autophagy signaling by quantitative phosphoproteomics

Characterization of early autophagy signaling by quantitative phosphoproteomics

dataset posted on 2025-02-24

Inducing autophagy

Inducing autophagy

dataset posted on 2025-02-24

HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury

HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury

journal contribution posted on 2025-02-10

FOXO-regulated DEAF1 controls muscle regeneration through autophagy

FOXO-regulated DEAF1 controls muscle regeneration through autophagy

journal contribution posted on 2024-07-04

PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction

PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction

journal contribution posted on 2024-06-19

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis

journal contribution posted on 2024-06-14

CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity

CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity

dataset posted on 2024-06-13

RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum

RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum

journal contribution posted on 2024-05-31

The mammalian actin elongation factor ENAH/MENA contributes to autophagosome formation via its actin regulatory function

The mammalian actin elongation factor ENAH/MENA contributes to autophagosome formation via its actin regulatory function

dataset posted on 2024-05-06

Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy

Deacetylation of ATG7 drives the induction of macroautophagy and LC3-associated microautophagy

journal contribution posted on 2023-11-24

Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling

Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling

dataset posted on 2023-11-08

Automated quantification of vacuole fusion and lipophagy in <i>Saccharomyces cerevisiae</i> from fluorescence and cryo-soft X-ray microscopy data using deep learning

Automated quantification of vacuole fusion and lipophagy in Saccharomyces cerevisiae from fluorescence and cryo-soft X-ray microscopy data using deep learning

dataset posted on 2023-11-01

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals

dataset posted on 2023-10-26

Invariant BECN1 CXXC motifs bind Zn<sup>2+</sup> and regulate structure and function of the BECN1 intrinsically disordered region

Invariant BECN1 CXXC motifs bind Zn²⁺ and regulate structure and function of the BECN1 intrinsically disordered region

journal contribution posted on 2023-10-04

Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer

Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer

journal contribution posted on 2023-09-29

Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network

Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network

journal contribution posted on 2023-08-31

Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy

Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy

journal contribution posted on 2023-07-20

Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)

Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin)

dataset posted on 2023-07-14

PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis

PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis

journal contribution posted on 2023-06-21

HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies

HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies

journal contribution posted on 2023-03-01

The LC3B FRET biosensor monitors the modes of action of ATG4B during autophagy in living cells

The LC3B FRET biosensor monitors the modes of action of ATG4B during autophagy in living cells

dataset posted on 2023-02-23

Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules

Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules

dataset posted on 2023-01-24

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

journal contribution posted on 2023-01-20

Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker

Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker

journal contribution posted on 2023-01-13

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

Copper-dependent autophagic degradation of GPX4 drives ferroptosis

journal contribution posted on 2023-01-09

The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma

The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma

journal contribution posted on 2022-12-01

Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region

Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region

journal contribution posted on 2022-11-17

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

journal contribution posted on 2022-10-27

Apicoplast biogenesis mediated by ATG8 requires the ATG12–ATG5-ATG16L and SNAP29 complexes in <i>Toxoplasma gondii</i>

Apicoplast biogenesis mediated by ATG8 requires the ATG12–ATG5-ATG16L and SNAP29 complexes in Toxoplasma gondii

dataset posted on 2022-09-12

RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1

RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1

journal contribution posted on 2022-08-22

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes

dataset posted on 2022-08-08

Secretory autophagy during lysosome inhibition (SALI)

Secretory autophagy during lysosome inhibition (SALI)

journal contribution posted on 2022-07-04

DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis

DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis

dataset posted on 2022-07-01

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine

journal contribution posted on 2022-05-04

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation

Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation

dataset posted on 2022-05-04

LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs

LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs

journal contribution posted on 2022-04-13

An optimized protocol for immuno-electron microscopy of endogenous LC3

An optimized protocol for immuno-electron microscopy of endogenous LC3

dataset posted on 2022-04-07

Phosphatidic acid suppresses autophagy through competitive inhibition by binding GAPC (glyceraldehyde-3-phosphate dehydrogenase) and PGK (phosphoglycerate kinase) proteins

Phosphatidic acid suppresses autophagy through competitive inhibition by binding GAPC (glyceraldehyde-3-phosphate dehydrogenase) and PGK (phosphoglycerate kinase) proteins

dataset posted on 2022-03-15

KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity

KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity

dataset posted on 2022-03-10