%PDF-1.5
%
1 0 obj
<>/OCGs[7 0 R]>>/Pages 3 0 R/Type/Catalog>>
endobj
2 0 obj
<>stream
application/pdf
Supplementary Figure 5
2016-06-01T10:37:13+02:00
2016-06-01T10:37:13+02:00
2016-06-01T10:37:13+02:00
Adobe Illustrator CS6 (Windows)
256
68
JPEG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uuid:4263b9ca-035a-49af-aa07-74cb99d8bbb2
xmp.did:AE9464F4D327E6118B18FF7911CDDD2D
uuid:5D20892493BFDB11914A8590D31508C8
proof:pdf
uuid:f855427b-0c3c-4c95-b82d-404c39dc808c
xmp.did:ED0D9A582B27E61189548A0829FAC4F4
uuid:5D20892493BFDB11914A8590D31508C8
default
saved
xmp.iid:FA7F1174072068118083E79AD876E79A
2016-01-13T23:04:24+01:00
Adobe Illustrator CS5.1
/
saved
xmp.iid:AE9464F4D327E6118B18FF7911CDDD2D
2016-06-01T10:37:05+02:00
Adobe Illustrator CS6 (Windows)
/
Print
False
False
1
209.197222
67.733333
Millimeters
ArialMT
Arial
Regular
Open Type
Version 5.22
False
arial.ttf
Arial-BoldMT
Arial
Bold
Open Type
Version 5.22
False
arialbd.ttf
Black
Default Swatch Group
0
White
CMYK
PROCESS
0.000000
0.000000
0.000000
0.000000
Black
CMYK
PROCESS
0.000000
0.000000
0.000000
100.000000
CMYK Red
CMYK
PROCESS
0.000000
100.000000
100.000000
0.000000
CMYK Yellow
CMYK
PROCESS
0.000000
0.000000
100.000000
0.000000
CMYK Green
CMYK
PROCESS
100.000000
0.000000
100.000000
0.000000
CMYK Cyan
CMYK
PROCESS
100.000000
0.000000
0.000000
0.000000
CMYK Blue
CMYK
PROCESS
100.000000
100.000000
0.000000
0.000000
CMYK Magenta
CMYK
PROCESS
0.000000
100.000000
0.000000
0.000000
C=15 M=100 Y=90 K=10
CMYK
PROCESS
14.999998
100.000000
90.000000
10.000002
C=0 M=90 Y=85 K=0
CMYK
PROCESS
0.000000
90.000000
85.000000
0.000000
C=0 M=80 Y=95 K=0
CMYK
PROCESS
0.000000
80.000000
95.000000
0.000000
C=0 M=50 Y=100 K=0
CMYK
PROCESS
0.000000
50.000000
100.000000
0.000000
C=0 M=35 Y=85 K=0
CMYK
PROCESS
0.000000
35.000004
85.000000
0.000000
C=5 M=0 Y=90 K=0
CMYK
PROCESS
5.000001
0.000000
90.000000
0.000000
C=20 M=0 Y=100 K=0
CMYK
PROCESS
19.999998
0.000000
100.000000
0.000000
C=50 M=0 Y=100 K=0
CMYK
PROCESS
50.000000
0.000000
100.000000
0.000000
C=75 M=0 Y=100 K=0
CMYK
PROCESS
75.000000
0.000000
100.000000
0.000000
C=85 M=10 Y=100 K=10
CMYK
PROCESS
85.000000
10.000002
100.000000
10.000002
C=90 M=30 Y=95 K=30
CMYK
PROCESS
90.000000
30.000002
95.000000
30.000002
C=75 M=0 Y=75 K=0
CMYK
PROCESS
75.000000
0.000000
75.000000
0.000000
C=80 M=10 Y=45 K=0
CMYK
PROCESS
80.000000
10.000002
45.000000
0.000000
C=70 M=15 Y=0 K=0
CMYK
PROCESS
70.000000
14.999998
0.000000
0.000000
C=85 M=50 Y=0 K=0
CMYK
PROCESS
85.000000
50.000000
0.000000
0.000000
C=100 M=95 Y=5 K=0
CMYK
PROCESS
100.000000
95.000000
5.000001
0.000000
C=100 M=100 Y=25 K=25
CMYK
PROCESS
100.000000
100.000000
25.000000
25.000000
C=75 M=100 Y=0 K=0
CMYK
PROCESS
75.000000
100.000000
0.000000
0.000000
C=50 M=100 Y=0 K=0
CMYK
PROCESS
50.000000
100.000000
0.000000
0.000000
C=35 M=100 Y=35 K=10
CMYK
PROCESS
35.000004
100.000000
35.000004
10.000002
C=10 M=100 Y=50 K=0
CMYK
PROCESS
10.000002
100.000000
50.000000
0.000000
C=0 M=95 Y=20 K=0
CMYK
PROCESS
0.000000
95.000000
19.999998
0.000000
C=25 M=25 Y=40 K=0
CMYK
PROCESS
25.000000
25.000000
39.999996
0.000000
C=40 M=45 Y=50 K=5
CMYK
PROCESS
39.999996
45.000000
50.000000
5.000001
C=50 M=50 Y=60 K=25
CMYK
PROCESS
50.000000
50.000000
60.000004
25.000000
C=55 M=60 Y=65 K=40
CMYK
PROCESS
55.000000
60.000004
65.000000
39.999996
C=25 M=40 Y=65 K=0
CMYK
PROCESS
25.000000
39.999996
65.000000
0.000000
C=30 M=50 Y=75 K=10
CMYK
PROCESS
30.000002
50.000000
75.000000
10.000002
C=35 M=60 Y=80 K=25
CMYK
PROCESS
35.000004
60.000004
80.000000
25.000000
C=40 M=65 Y=90 K=35
CMYK
PROCESS
39.999996
65.000000
90.000000
35.000004
C=40 M=70 Y=100 K=50
CMYK
PROCESS
39.999996
70.000000
100.000000
50.000000
C=50 M=70 Y=80 K=70
CMYK
PROCESS
50.000000
70.000000
80.000000
70.000000
Grays
1
C=0 M=0 Y=0 K=100
CMYK
PROCESS
0.000000
0.000000
0.000000
100.000000
C=0 M=0 Y=0 K=90
CMYK
PROCESS
0.000000
0.000000
0.000000
89.999405
C=0 M=0 Y=0 K=80
CMYK
PROCESS
0.000000
0.000000
0.000000
79.998795
C=0 M=0 Y=0 K=70
CMYK
PROCESS
0.000000
0.000000
0.000000
69.999702
C=0 M=0 Y=0 K=60
CMYK
PROCESS
0.000000
0.000000
0.000000
59.999104
C=0 M=0 Y=0 K=50
CMYK
PROCESS
0.000000
0.000000
0.000000
50.000000
C=0 M=0 Y=0 K=40
CMYK
PROCESS
0.000000
0.000000
0.000000
39.999401
C=0 M=0 Y=0 K=30
CMYK
PROCESS
0.000000
0.000000
0.000000
29.998802
C=0 M=0 Y=0 K=20
CMYK
PROCESS
0.000000
0.000000
0.000000
19.999701
C=0 M=0 Y=0 K=10
CMYK
PROCESS
0.000000
0.000000
0.000000
9.999103
C=0 M=0 Y=0 K=5
CMYK
PROCESS
0.000000
0.000000
0.000000
4.998803
Brights
1
C=0 M=100 Y=100 K=0
CMYK
PROCESS
0.000000
100.000000
100.000000
0.000000
C=0 M=75 Y=100 K=0
CMYK
PROCESS
0.000000
75.000000
100.000000
0.000000
C=0 M=10 Y=95 K=0
CMYK
PROCESS
0.000000
10.000002
95.000000
0.000000
C=85 M=10 Y=100 K=0
CMYK
PROCESS
85.000000
10.000002
100.000000
0.000000
C=100 M=90 Y=0 K=0
CMYK
PROCESS
100.000000
90.000000
0.000000
0.000000
C=60 M=90 Y=0 K=0
CMYK
PROCESS
60.000004
90.000000
0.003099
0.003099
Adobe PDF library 10.01
endstream
endobj
3 0 obj
<>
endobj
9 0 obj
<>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/XObject<>>>/Thumb 15 0 R/TrimBox[0.0 0.0 593.0 192.0]/Type/Page>>
endobj
10 0 obj
<>stream
HUnAW{c;$V0$x$.\,p'!|={c3%Zڣw' 5{3:Yhzh~"S!ҧu^7',;T8|i.q.w(] ןLTކ@6`nݼI7{$ףcG.d9"ƳSM*mVF<,[DjUFۜRJ{56 (k!$nCP8
hzQlLط\dàr@7u>;'t6]V()Ebr j}9lQG"66q;Bl0TبDF l&ow)dFms)NsҐio^cq/qekաN=}/&ȥ#Ë;~mjDRu:$* .ǢŃ3U}DbUV3У7l\UHE_-FDq}HG-D;*?ќj+R4~BU9@iS8eb lEN, /9bv8WP`IJPk1ێa\b+YjxGMPS9B*f%
6]D@+Eӳ3ޕ%Uz^<.WO+9XAe{m^-iyjZ fH7?:7;ngVD%.S q a
endstream
endobj
15 0 obj
<>stream
8;Z\rb7/tU$q!*MDe>U-PC:Y;?&,dXckB==JpQ?X3BD1EV5t#m)JR9Jl4"9\8@9Wi
kI1#>'5gMM[LtqloGu#g>oGW;adk8+DIOq*&VqLGBa
endstream
endobj
16 0 obj
[/Indexed/DeviceRGB 255 17 0 R]
endobj
17 0 obj
<>stream
8;X]O>EqN@%''O_@%e@?J;%+8(9e>X=MR6S?i^YgA3=].HDXF.R$lIL@"pJ+EP(%0
b]6ajmNZn*!='OQZeQ^Y*,=]?C.B+\Ulg9dhD*"iC[;*=3`oP1[!S^)?1)IZ4dup`
E1r!/,*0[*9.aFIR2&b-C#soRZ7Dl%MLY\.?d>Mn
6%Q2oYfNRF$$+ON<+]RUJmC0InDZ4OTs0S!saG>GGKUlQ*Q?45:CI&4J'_2j$XKrcYp0n+Xl_nU*O(
l[$6Nn+Z_Nq0]s7hs]`XX1nZ8&94a\~>
endstream
endobj
14 0 obj
<>stream
H,Yv8?=%72k:fR@ VwGit*}V[-tVr.O~{5^+JerV߽;SJ!9;{z/YNo+w6JV_ٙ:4akTg+<&,%ԂM)cȜ >Ta>Zut^rJ&)l륌gMYjeCҵTg89o6zm͵qH_{ dr^p4'6QDl^;gw4=gX!\NB+Izy&fIfŧ`gOYþxyG]LhUGGrVGǙ=g"smmUu{Yc/K9쁁̈z)8G,سwu&c,?LWRg^di
lmpw(<8.rl^TehnaT$jr21ZFEtke}~ \5gc1LklTؠO)uyO57s(T^6ų~Zt'+bnbSj_F鴷IJyCMܟʤSqxsxD4mrLQr9s>vԗ-D$w.5uY0<$g؏܆Zg ??<d8bĶKI0Ʒ(?xڳھ"d$U+w!sL 3Amur\H-3F,9i!Q6oq,V$E̠:fNhA
3 gcmxKG̺`{^Fm$kGÄAw88_s_r*]"?7|V
e *AO/]gh3Upw(ˋGEMOKFH$x!d!@}ScNq){`R)^o3Ӆ5@|&(V?6R|#Yć;N'i:kP
R02s=%3ω _&2j);ME}Y!o)_֤UZbDŠn1uU)D洲aio;SB