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Design, synthesis and herbicidal activity of novel cyclic phosphonates with diaryl ethers containing pyrimidine

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journal contribution
posted on 27.06.2019 by Shasha Zhang, Xinjuan Guo, Yuan Zhou, Yalan Yang, Hao Peng, Hongwu He

Thirteen novel cyclic phosphates were rationally designed and synthesized by introducing diary ethers containing pyrimidine. All the target compounds were characterized by 1H, 13C, 31P NMR and HRMS. The test of herbicidal activity indicated that most of the compounds showed good herbicidal activities against Amaranthus retroflexus. The compounds IA-2 (1-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)propyl-2-((4,6-dimethoxypyrimidin-2-yl)oxy)benzoate) and IA-3 ((5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)(phenyl)methyl-2-((4,6-dimethoxypyrimidin-2-yl)oxy)benzoate) exhibited remarkable post-emergency herbicidal activity against the tested monocotyledonous weed at the dosage of 112.5 g ai/ha.


This work was supported in part by the National Natural Science Foundation of China (21877047, 21172090), National research and development plan (No. 2017YFD0200506), the 111 Project B17019 and excellent doctoral dissertation cultivation grant from Central China Normal University (No. 2016YBZZ030).