Glutathione-Coated Magnetic Nanoparticles for One-Pot Synthesis of 1,4-Dihydropyridine Derivatives

A magnetic Fe₃O₄ supported glutathione catalyst was synthesized in a convenient and eco-friendly manner and characterized using FT-IR, XRD, TGA, TEM, VSM, EDX, and elemental analysis. This nano-organocatalyst exhibited excellent catalytic activity in the synthesis of a wide variety of 1,4-dihydropyridine derivatives. The catalyst was easily separated from the reaction mixture through using an external magnet and was reused in six consecutive runs with only a slight decrease in its catalytic activity. Other significant advantages of this method are shorter reaction time, excellent yield, simple work-up procedure, easy catalyst handling, and the high stability of the catalyst, which renders the protocol economic and sustainable.